Shinkowa Pharmaceutical Co., Ltd., Distributor of the World's First Supplements Containing β-Nicotinamide Mononucleotide (NMN), Has Begun World-Wide Distribution of the Special Products "NMN PURE 3000" and "NMN PURE 1500"

TOKYO- 18 October 2017- (BUSINESSWIRE/AETOSWire)--Shinkowa Pharmaceutical Co., Ltd. (Chuo-ward, Tokyo; CEO, Megumi Tanaka) sells the first ever original supplements and cosmetics containing β-nicotinamidemononucleotide (NMN) under the "MIRAILAB" supplement brand and the"MIRAIDA" cosmetic brand, respectively.
The company has begun world-wide distribution of the special supplement products "NMN PURE 3000" and "NMN PURE 1500", which contain high doses of NMN.

[About NMN]
NMN is an abbreviation of β-nicotinamide mononucleotide, which is contained in vitamin B3s and exists naturally in the tissues and cells of organisms.

NMN is transformed in the body to a substance called nicotinamide adenine dinucleotide (NAD), which is necessary for us to maintain body functions, and is known to enhance the activities of 7 types of sirtuin genes (SIRT 1-7) as well as the function of mitochondria within the cells.

Mitochondria produce adenosine triphosphate (ATP), known as the"molecular unit of currency", and play a role in providing energy to the cells. SIRT 1 is important in promoting the cooperation of the nucleus and mitochondria within the cells.

As mitochondria function decreases with aging, the production of NMN in the body decreases, and the amount of NAD decreases accordingly.
When taken orally, about 90% of the NAD is destroyed in the digestive organs,therefore NMN, which is not destroyed in the digestive organs, needs to be supplemented from outside the body. NMN intake enhances the function of mitochondria,and rejuvenation and anti-aging are anticipated with the activation of sirtuin genes.

Sirtuin genes play an important role in controlling aging and longevity.Proteins produced from sirtuin genes prevent aging and are involved in energy metabolism.
For example, the functions of the muscles, etc. are known to be kept young when the function of SIRT1 is enhanced by NMN in the hypothalamus of the brain. The hypothalamus is considered to play the role of the "control center"that regulates aging. Commands from the hypothalamus are conveyed to the skeletal muscles, and a hormone-like substance that adjusts the body function is excreted from the skeletal muscles to keep the muscles young. Therefore, NMNis expected to be effective not only for decreasing body functions associated with aging but also for locomotive syndrome, which makes walking difficult due to the weakening of the legs, and sarcopenia, which is associated with a decrease in muscle mass.

NMN is also expected to be effective for various functions that are weakened with aging and diseases, including the improvements in the blood glucose level in patients with type 2 diabetes and pre-diabetes in whom the blood glucose levels become higher than normal, prevention of Alzheimer's disease, neurodegenerative disease, heart failure, and metabolic syndrome, as well as increased bone mineral density and the improved immunity. These conditions have already been confirmed to be resolved and improved after treatment with NMN in studies with mice.