Study Shows Walnuts May have Anti-inflammatory Effects that Reduce Risk of Heart Disease

Findings from the largest and longest study exploring the benefits of walnuts show regular consumption in older adults may reduce the risk of heart disease by reducing the concentration of certain inflammatory biomarkers

FOLSOM, Calif., December 29, 2020 –(AETOSWire)– Findings from a randomized controlled trial recently published in the Journal of the American College of Cardiology, indicate that people in their 60s and 70s who regularly consume walnuts may have reduced inflammation, a factor associated with a lower risk of heart disease, compared to those who do not eat walnuts. The research was part of the Walnuts and Healthy Aging (WAHA) study – the largest and longest trial to date exploring the benefits of daily walnut consumption.

In the study, conducted by Dr. Emilio Ros from the Hospital Clinic of Barcelona, in partnership with Loma Linda University, more than 600 healthy older adults consumed 30 to 60 grams of walnuts per day as part of their typical diet or followed their standard diet (without walnuts) for two years. Those who consumed walnuts had a significant reduction in inflammation, measured by the concentration of known inflammatory markers in the blood, which were reduced by up to 11.5%. Of the 10 well-known inflammatory markers that were measured in the study, six were significantly reduced on the walnut diet, including interleukin-1β, a potent pro-inflammatory cytokine which pharmacologic inactivation has been strongly associated with reduced rates of coronary heart disease. The study’s conclusion is that the anti-inflammatory effects of walnuts provide a mechanistic explanation for cardiovascular disease reduction beyond cholesterol lowering.

“Acute inflammation is a physiological process due to activation of the immune system by injury such as trauma or infection, and is an important defense of the body”, says Dr. Emilio Ros, a lead researcher in the study. “Short-term inflammation helps us heal wounds and fight infections, but inflammation that persists overtime (chronic), caused by factors such as poor diet, obesity, stress and high blood pressure, is damaging instead of healing, particularly when it comes to cardiovascular health. The findings of this study suggest walnuts are one food that may lessen chronic inflammation, which could help to reduce the risk for heart disease – a condition we become more susceptible to as we age.”

While existing scientific evidence establishes walnuts as a heart-healthy3 food, researchers continue to investigate the “how” and “why” behind walnuts’ cardiovascular benefits. According to Dr. Ros, “Walnuts have an optimal mix of essential nutrients like the omega-3 alpha-linolenic acid, or ALA (2.5g/oz), and other highly bioactive components like polyphenols4, that likely play a role in their anti-inflammatory effect and other health benefits.”

References:

Cofán M, Rajaram S, Sala-Vila A, et al. Effects of 2-Year Walnut-Supplemented Diet on Inflammatory Biomarkers. [published online ahead of print November 2, 2020]. J Am Coll Cardiol. 2020 Nov, 76 (19) 2282–2284.